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Accueil du site > Research Teams > Organic & Medicinal chemistry > CESMA - Design and Synthesis of Analgesic Molecules > Project Guiera

Project Guiera

by Sylvie Ducki - 23 March 2012

All the versions of this article: English , français

Description

This project aims at studying the chemical composition and the pharmacological activity of a plant used in the Western African traditional pharmacopeia, and more particularly prescribed by Malians tradipraticians with the local populations in the treatment of the pain: Guiera senegalensis. Initially, an ethnobotanic investigation by the Malian tradipraticians enabled us to choose the places of collection of the material and selecting the parts to be taken on the plant (leaves, bark, roots …). After crushing and various extractions with organic solvents, we obtain several crude extracts whose analgesic activity is evaluated . The active fractions are then purified and the active ingredients isolated and identified in order to determine the most effective amount and inducing the minimum of adverse effects. Moreover, the mechanism of action of the most effective molecules will be studied.

Publications

Somboro A, Patel K, Diallo D, Sidibe L, Chalchat JC, Figueredo G, Ducki S, Troin Y, Chalard* P Journal of Medicinal Plant Research 2011, 5, 1639-1651 : “An ethnobotanical and phytochemical study of the African medicinal plant Guiera senegalensis J. F. Gmel “.

Chalard P, Patel K, Caldefie-Chezet F, Delort L. Brevet : FR 2011 58256, “Nouveau principe actif extrait de Guiera senegalensis à activité anticancéreuse”.

Grants

Bourse filière du Conseil Régional d’Auvergne / FEDER (2010-2011)

Ambassade de France de Bamako au Mali

Academic and industrial collaborations

Département de Médecine Traditionnelle (DMT) et la Faculté de Sciences et Technique (FAST) de Bamako, Mali.